CFB OGPAE01-1 Perinatal Medicine, Antenatal Care And Pre-pregnant Counselling (part I)

Perinatal medicine and antenatal care encompass the systematic medical supervision of pregnancy from preconception counseling through the prenatal period, including risk assessment, health optimization, and screening to ensure optimal maternal and fetal outcomes.

Antenatal Care and Pre-Pregnancy Counselling (Part I)

The lecture's destination is simple:

Healthy mother and healthy baby through prevention, early detection and education [1].

The practical sequence is:

What the slide images contribute

  • A detailed thalassaemia couple-risk flowchart, including α-, β- and discordant-carrier branches.
  • A fundal-height drawing with the 12-, 20- and 36-week landmarks and different rates of ascent below and above the umbilicus.
  • A cell-free DNA schematic showing that the DNA tested in maternal blood is predominantly placental in origin.
  • Side-by-side procedural drawings of CVS into placenta versus amniocentesis into the amniotic sac.
  • Diagrams separating fetal lie from presentation, followed by the sequence of an external cephalic version (ECV).

How to use slide-era numbers

Gestational windows, detection rates, miscarriage risks and local screening pathways are reproduced as the deck teaches them. They describe the 2024 TYH/QMH lecture pathway, not timeless universal rules. Current guidance and local protocols should govern clinical care, especially where a correction is flagged below.


MaternalFetal
General health, especially anaemiaIncorrect gestational age
Common infectionsMultiple pregnancy
Gestational diabetes and hypertensive disordersCongenital abnormalities
Medication, blood group and social risksAbnormal growth
Abnormal lie or presentation

The lecture groups screening tools into four layers [1]:

  1. History — medical and obstetric history, menstrual dates, age, family history, exposures, habits and current symptoms.
  2. Examination — weight/height, general examination, blood pressure, urinalysis and uterine size.
  3. Routine investigations — haemoglobin, blood group/Rh status, infection testing and ultrasound.
  4. Specific programmes — notably thalassaemia and fetal aneuploidy screening.

The point is not to order everything at every visit. It is to match each problem to the right test and gestational window.


2. Maternal screening

The slide's routine investigation list includes Hb, HBsAg, rubella status, Rh blood group, VDRL/syphilis testing, HIV testing and ultrasound [1]. Add a full blood count/MCV, antibody screen, urine assessment and any locally indicated tests. Exact booking panels differ by service.

At each visit, reassess rather than merely repeat a checklist:

  • maternal symptoms and wellbeing;
  • blood pressure and pre-eclampsia symptoms;
  • urine testing according to protocol;
  • uterine/fetal growth and fetal movement at the appropriate gestation;
  • adherence, medicines, safeguarding and psychosocial needs.

The deck checks Hb at booking and again at 26 weeks [1]. The repeat looks for anaemia emerging as iron requirement and plasma volume rise later in pregnancy.

ClueMain possibilitiesNext step
Low Hb + low MCVIron deficiency, thalassaemia, or bothFerritin plus haemoglobinopathy pathway
Low Hb + normal/high MCVFolate/B12 deficiency, haemolysis, inflammation or other causeReticulocytes, film and targeted tests
Pallor or symptomsAnaemia may be clinically importantConfirm Hb and assess severity/cause

Do not assume microcytosis is iron deficiency and prescribe indefinitely without checking ferritin and carrier status.

Thalassaemia screening: reading the full flowchart

The original 2003 HKCOG chart printed an MCV cut-off of 80 fL, while the lecture overlays 82 at each decision node. For this deck, the examinable cut-off is therefore MCV < 82 fL, but laboratories/programmes may use different validated thresholds [1][16].

  • Raised HbA₂ supports β-thalassaemia trait.
  • HbH inclusions support α-thalassaemia, but their absence does not exclude α⁰ carrier status.
  • Low MCV with normal Hb pattern/HbA₂, no HbH inclusions and normal iron can still represent α-thalassaemia; the chart explicitly says to manage such a couple as a potential α⁰ couple until clarified [1].
  • One person can carry both α- and β-thalassaemia variants. Therefore an apparently discordant α/β couple can still be at risk of Hb Bart's hydrops fetalis if the β-thalassaemia partner also carries an α⁰ deletion.

At-risk coupleSevere fetal outcomeDiagnostic logic shown in chart
Both carry α⁰ deletionsHomozygous α⁰-thalassaemia → Hb Bart's hydrops fetalisDetermine fetal α-globin genotype; serial ultrasound can show an affected fetus but is not the same as definitive genotyping
Both carry pathogenic β-globin variantsβ-thalassaemia majorDefine parental variants, then test fetal DNA
Apparent α/β discordanceHidden α⁰ couple riskGenotype the β-thalassaemia partner's α genes

The old chart includes CVS at 10–12 weeks, amniocentesis at 18 weeks and serial scans from 12 weeks [1]. The same deck's later procedural table gives CVS 11–14 weeks and amniocentesis 16–20 weeks. Use the current fetal-medicine service window rather than memorising the older chart's exact timing.

The deck lists routine HBsAg, syphilis, HIV and GBS screening, plus targeted STI/urine/vaginal testing when indicated [1]. Read it as a timing map:

Infection/problemTest or actionDeck timing/logic
Hepatitis BHBsAg at bookingEnables maternal assessment and neonatal immunoprophylaxis planning
SyphilisSerology at bookingTreatable cause of major fetal harm
HIVOpt-out/consented testing according to serviceAntiretroviral and delivery/feeding planning markedly reduce transmission
Rubella susceptibilityIgG/status in the booking panelLive vaccine is not given during pregnancy; offer postpartum if non-immune
Group B streptococcusLow vaginal and rectal swabsDeck uses 35–37 weeks; timing and universal/risk-based policy vary by jurisdiction
Symptoms or high-risk sexual historyTargeted swabs/NAATs and broader STI screenOne STI should prompt assessment for others

Do not equate protein on a contaminated urine dipstick with renal proteinuria; assess sample quality and send a midstream urine specimen when UTI is possible.

The deck combines risk-factor assessment with a universal 75 g oral glucose tolerance test (OGTT) pathway [1]:

  • Early OGTT between booking and 16 weeks if risk factors are present: obesity, age ≥35, PCOS, family history of diabetes, previous infant > 4 kg, unexplained stillbirth, previous unexplained abnormal baby or multiple pregnancy.
  • Routine OGTT at 26–32 weeks if no listed risk factor.

This is the local lecture algorithm. Many international protocols use 24–28 weeks for routine diagnosis, with earlier testing aimed at detecting overt pre-existing diabetes or early dysglycaemia [17]. Follow the local laboratory thresholds and maternity protocol.

Why it matters: hyperglycaemia increases risks of fetal overgrowth, shoulder dystocia, neonatal hypoglycaemia, pre-eclampsia and later type 2 diabetes in the mother.

The slide defines gestational hypertension as BP ≥140 systolic or ≥90 diastolic on two readings more than four hours apart after 20 weeks in a previously normotensive woman [1]. Severe hypertension may need confirmation and treatment sooner rather than waiting four hours.

DiagnosisWorking definition
Chronic hypertensionPresent before pregnancy, at booking/before 20 weeks, or already treated when referred
Gestational hypertensionNew hypertension after 20 weeks without criteria for pre-eclampsia
Pre-eclampsiaNew hypertension after 20 weeks plus proteinuria, maternal organ dysfunction or uteroplacental dysfunction
Superimposed pre-eclampsiaNew pre-eclamptic features in chronic hypertension

Important correction: proteinuria is not compulsory

The slide's shorthand “hypertension + albuminuria” is incomplete. Pre-eclampsia may be diagnosed without proteinuria when new renal, hepatic, neurological, haematological or uteroplacental dysfunction is present. If dipstick is positive, quantify when possible; NICE uses urine protein:creatinine ≥30 mg/mmol or albumin:creatinine ≥8 mg/mmol as significant thresholds [18].


3. Fetal screening

  1. LMP assumes a known date and ovulation about 14 days later; it becomes unreliable with uncertain dates, irregular/long cycles or recent hormonal contraception.
  2. Clinical uterine size offers a reasonableness check but is altered by fetal number, liquor volume, fibroids, abdominal wall thickness, lie and engagement.
  3. Early ultrasound is the best dating method when dates are uncertain. Accuracy progressively decreases with gestation because biological size variation and pathological growth become larger.

The slide's dating accuracy table [1]:

GestationApproximate accuracy stated in deck
Before 12 weeks±4–5 days
13–14 weeks±1 week
14–20 weeks±10 days
20–24 weeks±2 weeks
After 24 weeksPoor for establishing gestational age

Once a reliable early due date has been assigned, later biometry is primarily interpreted as growth, not an invitation to keep redating the pregnancy.

The figure is a schematic for a singleton pregnancy [1]:

  • 12 weeks: fundus just above the symphysis pubis.
  • 20 weeks: fundus at the umbilicus.
  • 36 weeks: fundus approaches the xiphisternum.
  • Below the umbilicus, the drawing shows growth of roughly two finger-breadths every two weeks.
  • Above the umbilicus, it shows roughly one finger-breadth every two weeks.

For serial screening later in pregnancy, measure symphysis–fundal height from the upper border of the symphysis to the uterine fundus. The deck's rule is SFH in cm ≈ gestational weeks ±2; the trajectory is more informative than one isolated value.

Clues include ovulation induction/assisted reproduction, maternal family history of dizygotic twinning, exaggerated pregnancy symptoms, a uterus large for dates, multiple fetal poles or separate heart rates. Ultrasound is the earliest reliable confirmation [1]. Determine chorionicity and amnionicity early, because surveillance and complication risk depend on placental sharing.

The deck states that an 18–20-week scan detects about 70% of major anomalies, with lower performance when BMI is high or fetal position is unfavourable [1]. Detection varies by anomaly, gestation, equipment and operator; the following are deck figures, not universal counselling guarantees:

AnomalyDetection rate shown
Anencephaly98%
Gastroschisis98%
Open spina bifida90%
Bilateral renal agenesis84%
Exomphalos80%
Cleft lip75%
Hydrocephalus60%
Diaphragmatic hernia60%
Lethal skeletal dysplasia60%
Serious cardiac anomalies50%

The cardiac row groups TGA, AVSD, tetralogy of Fallot and hypoplastic left heart syndrome. A four-chamber view alone can miss outflow-tract abnormalities, so a systematic cardiac survey includes outflow and other standard views.

Fetal aneuploidy screening: deck pathway and current choice

TestGestationComponentsDetection rate shown for trisomy 21
First-trimester combined screening11 to 13+6 weeksNuchal translucency + PAPP-A + hCGUp to 90%
Second-trimester quadruple screening14 to 19+6 weeksAFP + hCG + unconjugated estriol + inhibin AAround 80%

An enlarged nuchal translucency is not synonymous with trisomy 21: it is also associated with other chromosomal conditions and structural abnormalities, particularly cardiac disease.

The slide's maternal-age table gives trisomy 21 risks ranging from about 1:700 at age 30, 1:450 at 35, 1:200 at 38, 1:100 at 40, 1:60 at 42 and 1:40 at 44 [1]. These are historical population estimates used to show the steep age gradient, not an individual diagnosis.

Current counselling principle

Do not tell an older pregnant patient that she must screen before diagnostic testing. Current guidance is to discuss and offer both screening and diagnostic options to every pregnant patient, regardless of age or baseline risk, after which the patient may pursue or decline either [19]. If screening is chosen, use one coherent screening strategy rather than multiple independent screens.

The diagram shows placental DNA fragments entering maternal circulation, a maternal blood tube containing a mixture of maternal and placental cell-free DNA, and counting/analysis of chromosome fragments for trisomies 21, 18 and 13 [1].

  • The deck quotes 99.7% detection of trisomy 21 with about a 0.1% false-positive rate; performance depends on platform, population and test conditions.
  • cfDNA is the most sensitive and specific screen for the common trisomies, but it is not diagnostic [19].
  • A positive result needs genetic counselling, detailed ultrasound and an offer of CVS or amniocentesis for confirmation.
  • A “no-call” result is not reassuring; low fetal fraction and placental biology can make the result uninterpretable and require further counselling/testing.
  • Because the analysed DNA is placental, confined placental mosaicism is one reason screen and fetus can disagree.

FeatureCVSAmniocentesis
Deck window11–14 weeks16–20 weeks
Needle destination in picturePlacenta/chorionic villiThrough membranes into amniotic fluid
What is sampledPlacental tissueFluid containing fetal cells
AdvantageEarlier definitive resultDirect sampling of amniotic fluid/fetal cells; less confined placental mosaicism issue
Procedure-related miscarriage risk shown0.1–0.2%0.1–0.2%

Both pictures show a transabdominal needle under ultrasound guidance. The risk numbers are the deck's counselling figures and vary with patient, procedure and centre. CVS can reveal confined placental mosaicism; selected results may require amniocentesis for clarification.

TermMeaning
Small for gestational age (SGA)Size/estimated weight below a centile threshold; may be constitutional or pathological
Fetal growth restriction (FGR)Failure to achieve growth potential because of pathology; not identical to SGA
Large for gestational age (LGA)Size/estimated weight above a centile threshold
MacrosomiaHigh absolute birth weight; cut-off varies by context

Serial SFH is a screen, not a diagnosis. A static/falling trajectory or discrepancy from dates prompts ultrasound biometry, liquor assessment and—when indicated—Doppler surveillance. The deck notes that routine ultrasound in an otherwise low-risk pregnancy had not shown clear effectiveness for detecting all growth problems [1]; high-risk pregnancies follow condition-specific scan schedules.

The two picture slides answer different questions [1]:

  • Lie: relation of the fetal long axis to the uterine long axis—longitudinal, transverse or oblique.
  • Presentation: fetal part at the pelvic inlet—cephalic, breech or shoulder. A transverse lie generally presents a shoulder.

Before 32–34 weeks, a non-cephalic lie in a patient not in labour often has little significance because there is room to turn. Most fetuses become longitudinal/cephalic by 35–36 weeks. For persistent breech after 36 weeks, assess suitability for ECV.

The ECV image shows a forward-roll sequence: the clinician elevates the breech out of the pelvis, guides the fetal poles through a forward or backward roll, and finishes with the vertex over the pelvis. It is an ultrasound/monitoring-supported hospital procedure performed by trained clinicians where urgent delivery is available—not a bedside manoeuvre to attempt casually.


4. The care system, birth planning and education

  • Exclusive specialist hospital care, public or private.
  • Primary-care or midwife-led care with referral when indicated.
  • Shared care between hospital and primary care/Maternal and Child Health Centre [1].

Risk is dynamic. A patient may begin in a low-risk pathway and need escalation when hypertension, abnormal growth, multiple pregnancy or another complication appears.

The deck reviews the plan at about 36 weeks in an uncomplicated pregnancy [1]:

  • allow spontaneous labour at term when mother and fetus remain well;
  • consider earlier delivery when maternal or fetal compromise changes the balance;
  • discuss induction around 41 weeks if pregnancy otherwise continues;
  • aim for vaginal birth unless an obstetric or maternal indication favours caesarean delivery.

The slide includes antenatal classes/exercise, contraception, family involvement, social support, special needs and patient groups [1]. Practical counselling should also cover warning symptoms, fetal movements, medicines/substances, nutrition, folic acid before conception/early pregnancy, vaccination, feeding intentions, birth planning and postpartum contraception. Tailor advice rather than handing over an undifferentiated list.

If cervical screening is up to date, the lecture does not add a routine test solely because of pregnancy. If overdue, assess whether screening during pregnancy or planned postpartum screening is most appropriate under the local programme [1].


5. Pre-pregnancy counselling

Ask two directions of risk:

  1. How can the disease affect pregnancy and the fetus?
  2. How can pregnancy affect the disease?

Then convert that discussion into actions:

  • define whether pregnancy is currently safe and when conception is best;
  • optimise disease activity, organ function, nutrition, weight and glycaemic control;
  • review every prescribed, over-the-counter and complementary medicine;
  • choose effective contraception until optimisation is complete;
  • assess recurrence/inheritance risk and arrange genetic counselling when relevant;
  • plan specialist team, antenatal surveillance, delivery and postpartum care.

The lecture lists higher risks of miscarriage, FGR, preterm birth, pre-eclampsia, neonatal lupus and variable maternal flares [1]. Anti-Ro/SSA and anti-La/SSB antibodies are relevant to neonatal lupus and congenital heart block. Conception is safest when disease is quiescent and medications/renal status have been reviewed by rheumatology and maternal medicine.

Medicine/contextSafe counselling principle
ACE inhibitor/ARBUsually avoid in pregnancy; make a supervised antihypertensive plan before conception
Warfarin or a mechanical heart valveAnticoagulation is highly individualised; do not simply “switch to LMWH” without an expert valve/obstetric plan
Methotrexate, mycophenolate, valproate and other teratogensReview indication, safer alternatives, washout where needed and effective contraception with the relevant specialist
Hydroxychloroquine in SLECommonly continued because stopping may increase flare risk; confirm the individual plan
Diabetes therapyAchieve safe preconception glycaemia and review drugs, retinal/renal status and folate plan

The durable principle is do not stop an essential medicine abruptly and do not conceive until the disease and medicine plan are ready.


6. Linked exam extensions

Late in pregnancy, the gravid uterus can compress the inferior vena cava when supine, reducing venous return and cardiac output. Dizziness that improves in the left lateral position supports the diagnosis; reposition and assess for other causes if symptoms persist or red flags are present [8][11].

TrapBetter answer
“Low MCV means iron deficiency”Check ferritin and the haemoglobinopathy pathway; both can coexist
“No HbH inclusions excludes α-thalassaemia”α⁰ carrier status can be missed; genotype at-risk couples
“Pre-eclampsia requires proteinuria”Organ or uteroplacental dysfunction can establish it without proteinuria
“Advanced age means screening first”Offer screening and diagnostic options after informed counselling
“NIPT is diagnostic”It analyses placental cfDNA and positive results require confirmatory CVS/amnio
“Late ultrasound can re-date the pregnancy”Use a reliable early date; later size mainly assesses growth
“Lie and presentation are synonyms”Lie is axis-to-axis; presentation is the fetal part at the pelvic inlet

  • 2020 Fourth Summative MCQ Q6–7: early OGTT in a patient with a diabetes risk factor [4].
  • 2023 Fourth Summative MCQ Q13–14: hypertension/proteinuria classification and first-trimester aneuploidy screening [10].
  • 2023 and 2025 Fourth Summative SAQs: antenatal screening and related pregnancy physiology [7][8].
  • 2021 Fourth Summative MCQ Q9: supine hypotension [11].

Exact wording and mark allocation should be checked in the original papers.

High-yield summary

  1. Antenatal care combines prevention, screening and education.
  2. Read the thalassaemia chart as a couple-risk algorithm: woman → partner → characterise α/β status → fetal diagnosis when both can transmit severe disease.
  3. Date early; use later biometry to assess growth, not repeatedly change the due date.
  4. Pre-eclampsia is hypertension plus proteinuria or maternal/uteroplacental dysfunction.
  5. cfDNA/NIPT is highly accurate screening of placental DNA, not diagnosis.
  6. CVS samples placenta; amniocentesis samples amniotic fluid.
  7. Lie describes axes; presentation describes the part entering the pelvis.
  8. Preconception care optimises disease, medicines, inheritance risk and timing before contraception is stopped.

Active Recall - Antenatal Care and Pre-Pregnancy Counselling (Part I)

[1] Lecture slides: CFB (OGPAE01-1) Perinatal Medicine, Antenatal Care and Pre-pregnant Counselling (Part I).pdf (slides 1–43) [2] Lecture slides: CFB (PAE01) Paediatric history taking.pdf (p4) [3] Senior notes: Adrian Lui Obstetric Notes.pdf (p17, p24) [4] Past papers: 2020 Fourth Summative Assessment MCQ paper.pdf (p36, Q6–7) [5] Senior notes: Block A - Many members of the family have anaemia.pdf (p10, p36) [6] Senior notes: MBBS Final MB (Pediatrics) (Felix PY Lai).pdf (p589) [7] Past papers: 2025 Fourth Summative SAQ.pdf (p9, Q7) [8] Past papers: 2023 Fourth Summative SAQ.pdf (p3, Q2; p6, Q5) [10] Past papers: 2023 Fourth Summative MCQ.pdf (p6, Q13–14) [11] Past papers: 2021 Fourth Summative Assessment MCQ.pdf (p4, Q9) [13] Senior notes: Ryan Ho Fundamentals.pdf (p191) [14] Senior notes: Adrian Lui Pediatrics Notes.pdf (p20) [15] Lecture slides: Block C - O&G Theme Case 1.docx.pdf (p7) [16] Hong Kong College of Obstetricians and Gynaecologists: Guidelines of Antenatal Thalassaemia Screening [17] WHO recommendations on antenatal care for a positive pregnancy experience [18] NICE: Hypertension in pregnancy—diagnosis and management [19] ACOG: Current guidance on prenatal genetic screening and diagnostic testing

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