CFB OGPAE01-1 Perinatal Medicine, Antenatal Care And Pre-pregnant Counselling (part I)
Perinatal medicine and antenatal care encompass the systematic medical supervision of pregnancy from preconception counseling through the prenatal period, including risk assessment, health optimization, and screening to ensure optimal maternal and fetal outcomes.
Antenatal Care and Pre-Pregnancy Counselling (Part I)
The lecture's destination is simple:
Healthy mother and healthy baby through prevention, early detection and education [1].
The practical sequence is:
What the slide images contribute
- A detailed thalassaemia couple-risk flowchart, including α-, β- and discordant-carrier branches.
- A fundal-height drawing with the 12-, 20- and 36-week landmarks and different rates of ascent below and above the umbilicus.
- A cell-free DNA schematic showing that the DNA tested in maternal blood is predominantly placental in origin.
- Side-by-side procedural drawings of CVS into placenta versus amniocentesis into the amniotic sac.
- Diagrams separating fetal lie from presentation, followed by the sequence of an external cephalic version (ECV).
How to use slide-era numbers
Gestational windows, detection rates, miscarriage risks and local screening pathways are reproduced as the deck teaches them. They describe the 2024 TYH/QMH lecture pathway, not timeless universal rules. Current guidance and local protocols should govern clinical care, especially where a correction is flagged below.
| Maternal | Fetal |
|---|---|
| General health, especially anaemia | Incorrect gestational age |
| Common infections | Multiple pregnancy |
| Gestational diabetes and hypertensive disorders | Congenital abnormalities |
| Medication, blood group and social risks | Abnormal growth |
| Abnormal lie or presentation |
The lecture groups screening tools into four layers [1]:
- History — medical and obstetric history, menstrual dates, age, family history, exposures, habits and current symptoms.
- Examination — weight/height, general examination, blood pressure, urinalysis and uterine size.
- Routine investigations — haemoglobin, blood group/Rh status, infection testing and ultrasound.
- Specific programmes — notably thalassaemia and fetal aneuploidy screening.
The point is not to order everything at every visit. It is to match each problem to the right test and gestational window.
2. Maternal screening
The slide's routine investigation list includes Hb, HBsAg, rubella status, Rh blood group, VDRL/syphilis testing, HIV testing and ultrasound [1]. Add a full blood count/MCV, antibody screen, urine assessment and any locally indicated tests. Exact booking panels differ by service.
At each visit, reassess rather than merely repeat a checklist:
- maternal symptoms and wellbeing;
- blood pressure and pre-eclampsia symptoms;
- urine testing according to protocol;
- uterine/fetal growth and fetal movement at the appropriate gestation;
- adherence, medicines, safeguarding and psychosocial needs.
The deck checks Hb at booking and again at 26 weeks [1]. The repeat looks for anaemia emerging as iron requirement and plasma volume rise later in pregnancy.
| Clue | Main possibilities | Next step |
|---|---|---|
| Low Hb + low MCV | Iron deficiency, thalassaemia, or both | Ferritin plus haemoglobinopathy pathway |
| Low Hb + normal/high MCV | Folate/B12 deficiency, haemolysis, inflammation or other cause | Reticulocytes, film and targeted tests |
| Pallor or symptoms | Anaemia may be clinically important | Confirm Hb and assess severity/cause |
Do not assume microcytosis is iron deficiency and prescribe indefinitely without checking ferritin and carrier status.
Thalassaemia screening: reading the full flowchart
The original 2003 HKCOG chart printed an MCV cut-off of 80 fL, while the lecture overlays 82 at each decision node. For this deck, the examinable cut-off is therefore MCV < 82 fL, but laboratories/programmes may use different validated thresholds [1][16].
- Raised HbA₂ supports β-thalassaemia trait.
- HbH inclusions support α-thalassaemia, but their absence does not exclude α⁰ carrier status.
- Low MCV with normal Hb pattern/HbA₂, no HbH inclusions and normal iron can still represent α-thalassaemia; the chart explicitly says to manage such a couple as a potential α⁰ couple until clarified [1].
- One person can carry both α- and β-thalassaemia variants. Therefore an apparently discordant α/β couple can still be at risk of Hb Bart's hydrops fetalis if the β-thalassaemia partner also carries an α⁰ deletion.
| At-risk couple | Severe fetal outcome | Diagnostic logic shown in chart |
|---|---|---|
| Both carry α⁰ deletions | Homozygous α⁰-thalassaemia → Hb Bart's hydrops fetalis | Determine fetal α-globin genotype; serial ultrasound can show an affected fetus but is not the same as definitive genotyping |
| Both carry pathogenic β-globin variants | β-thalassaemia major | Define parental variants, then test fetal DNA |
| Apparent α/β discordance | Hidden α⁰ couple risk | Genotype the β-thalassaemia partner's α genes |
The old chart includes CVS at 10–12 weeks, amniocentesis at 18 weeks and serial scans from 12 weeks [1]. The same deck's later procedural table gives CVS 11–14 weeks and amniocentesis 16–20 weeks. Use the current fetal-medicine service window rather than memorising the older chart's exact timing.
The deck lists routine HBsAg, syphilis, HIV and GBS screening, plus targeted STI/urine/vaginal testing when indicated [1]. Read it as a timing map:
| Infection/problem | Test or action | Deck timing/logic |
|---|---|---|
| Hepatitis B | HBsAg at booking | Enables maternal assessment and neonatal immunoprophylaxis planning |
| Syphilis | Serology at booking | Treatable cause of major fetal harm |
| HIV | Opt-out/consented testing according to service | Antiretroviral and delivery/feeding planning markedly reduce transmission |
| Rubella susceptibility | IgG/status in the booking panel | Live vaccine is not given during pregnancy; offer postpartum if non-immune |
| Group B streptococcus | Low vaginal and rectal swabs | Deck uses 35–37 weeks; timing and universal/risk-based policy vary by jurisdiction |
| Symptoms or high-risk sexual history | Targeted swabs/NAATs and broader STI screen | One STI should prompt assessment for others |
Do not equate protein on a contaminated urine dipstick with renal proteinuria; assess sample quality and send a midstream urine specimen when UTI is possible.
The deck combines risk-factor assessment with a universal 75 g oral glucose tolerance test (OGTT) pathway [1]:
- Early OGTT between booking and 16 weeks if risk factors are present: obesity, age ≥35, PCOS, family history of diabetes, previous infant > 4 kg, unexplained stillbirth, previous unexplained abnormal baby or multiple pregnancy.
- Routine OGTT at 26–32 weeks if no listed risk factor.
This is the local lecture algorithm. Many international protocols use 24–28 weeks for routine diagnosis, with earlier testing aimed at detecting overt pre-existing diabetes or early dysglycaemia [17]. Follow the local laboratory thresholds and maternity protocol.
Why it matters: hyperglycaemia increases risks of fetal overgrowth, shoulder dystocia, neonatal hypoglycaemia, pre-eclampsia and later type 2 diabetes in the mother.
The slide defines gestational hypertension as BP ≥140 systolic or ≥90 diastolic on two readings more than four hours apart after 20 weeks in a previously normotensive woman [1]. Severe hypertension may need confirmation and treatment sooner rather than waiting four hours.
| Diagnosis | Working definition |
|---|---|
| Chronic hypertension | Present before pregnancy, at booking/before 20 weeks, or already treated when referred |
| Gestational hypertension | New hypertension after 20 weeks without criteria for pre-eclampsia |
| Pre-eclampsia | New hypertension after 20 weeks plus proteinuria, maternal organ dysfunction or uteroplacental dysfunction |
| Superimposed pre-eclampsia | New pre-eclamptic features in chronic hypertension |
Important correction: proteinuria is not compulsory
The slide's shorthand “hypertension + albuminuria” is incomplete. Pre-eclampsia may be diagnosed without proteinuria when new renal, hepatic, neurological, haematological or uteroplacental dysfunction is present. If dipstick is positive, quantify when possible; NICE uses urine protein:creatinine ≥30 mg/mmol or albumin:creatinine ≥8 mg/mmol as significant thresholds [18].
3. Fetal screening
- LMP assumes a known date and ovulation about 14 days later; it becomes unreliable with uncertain dates, irregular/long cycles or recent hormonal contraception.
- Clinical uterine size offers a reasonableness check but is altered by fetal number, liquor volume, fibroids, abdominal wall thickness, lie and engagement.
- Early ultrasound is the best dating method when dates are uncertain. Accuracy progressively decreases with gestation because biological size variation and pathological growth become larger.
The slide's dating accuracy table [1]:
| Gestation | Approximate accuracy stated in deck |
|---|---|
| Before 12 weeks | ±4–5 days |
| 13–14 weeks | ±1 week |
| 14–20 weeks | ±10 days |
| 20–24 weeks | ±2 weeks |
| After 24 weeks | Poor for establishing gestational age |
Once a reliable early due date has been assigned, later biometry is primarily interpreted as growth, not an invitation to keep redating the pregnancy.
The figure is a schematic for a singleton pregnancy [1]:
- 12 weeks: fundus just above the symphysis pubis.
- 20 weeks: fundus at the umbilicus.
- 36 weeks: fundus approaches the xiphisternum.
- Below the umbilicus, the drawing shows growth of roughly two finger-breadths every two weeks.
- Above the umbilicus, it shows roughly one finger-breadth every two weeks.
For serial screening later in pregnancy, measure symphysis–fundal height from the upper border of the symphysis to the uterine fundus. The deck's rule is SFH in cm ≈ gestational weeks ±2; the trajectory is more informative than one isolated value.
Clues include ovulation induction/assisted reproduction, maternal family history of dizygotic twinning, exaggerated pregnancy symptoms, a uterus large for dates, multiple fetal poles or separate heart rates. Ultrasound is the earliest reliable confirmation [1]. Determine chorionicity and amnionicity early, because surveillance and complication risk depend on placental sharing.
The deck states that an 18–20-week scan detects about 70% of major anomalies, with lower performance when BMI is high or fetal position is unfavourable [1]. Detection varies by anomaly, gestation, equipment and operator; the following are deck figures, not universal counselling guarantees:
| Anomaly | Detection rate shown |
|---|---|
| Anencephaly | 98% |
| Gastroschisis | 98% |
| Open spina bifida | 90% |
| Bilateral renal agenesis | 84% |
| Exomphalos | 80% |
| Cleft lip | 75% |
| Hydrocephalus | 60% |
| Diaphragmatic hernia | 60% |
| Lethal skeletal dysplasia | 60% |
| Serious cardiac anomalies | 50% |
The cardiac row groups TGA, AVSD, tetralogy of Fallot and hypoplastic left heart syndrome. A four-chamber view alone can miss outflow-tract abnormalities, so a systematic cardiac survey includes outflow and other standard views.
Fetal aneuploidy screening: deck pathway and current choice
| Test | Gestation | Components | Detection rate shown for trisomy 21 |
|---|---|---|---|
| First-trimester combined screening | 11 to 13+6 weeks | Nuchal translucency + PAPP-A + hCG | Up to 90% |
| Second-trimester quadruple screening | 14 to 19+6 weeks | AFP + hCG + unconjugated estriol + inhibin A | Around 80% |
An enlarged nuchal translucency is not synonymous with trisomy 21: it is also associated with other chromosomal conditions and structural abnormalities, particularly cardiac disease.
The slide's maternal-age table gives trisomy 21 risks ranging from about 1:700 at age 30, 1:450 at 35, 1:200 at 38, 1:100 at 40, 1:60 at 42 and 1:40 at 44 [1]. These are historical population estimates used to show the steep age gradient, not an individual diagnosis.
Current counselling principle
Do not tell an older pregnant patient that she must screen before diagnostic testing. Current guidance is to discuss and offer both screening and diagnostic options to every pregnant patient, regardless of age or baseline risk, after which the patient may pursue or decline either [19]. If screening is chosen, use one coherent screening strategy rather than multiple independent screens.
The diagram shows placental DNA fragments entering maternal circulation, a maternal blood tube containing a mixture of maternal and placental cell-free DNA, and counting/analysis of chromosome fragments for trisomies 21, 18 and 13 [1].
- The deck quotes 99.7% detection of trisomy 21 with about a 0.1% false-positive rate; performance depends on platform, population and test conditions.
- cfDNA is the most sensitive and specific screen for the common trisomies, but it is not diagnostic [19].
- A positive result needs genetic counselling, detailed ultrasound and an offer of CVS or amniocentesis for confirmation.
- A “no-call” result is not reassuring; low fetal fraction and placental biology can make the result uninterpretable and require further counselling/testing.
- Because the analysed DNA is placental, confined placental mosaicism is one reason screen and fetus can disagree.
| Feature | CVS | Amniocentesis |
|---|---|---|
| Deck window | 11–14 weeks | 16–20 weeks |
| Needle destination in picture | Placenta/chorionic villi | Through membranes into amniotic fluid |
| What is sampled | Placental tissue | Fluid containing fetal cells |
| Advantage | Earlier definitive result | Direct sampling of amniotic fluid/fetal cells; less confined placental mosaicism issue |
| Procedure-related miscarriage risk shown | 0.1–0.2% | 0.1–0.2% |
Both pictures show a transabdominal needle under ultrasound guidance. The risk numbers are the deck's counselling figures and vary with patient, procedure and centre. CVS can reveal confined placental mosaicism; selected results may require amniocentesis for clarification.
| Term | Meaning |
|---|---|
| Small for gestational age (SGA) | Size/estimated weight below a centile threshold; may be constitutional or pathological |
| Fetal growth restriction (FGR) | Failure to achieve growth potential because of pathology; not identical to SGA |
| Large for gestational age (LGA) | Size/estimated weight above a centile threshold |
| Macrosomia | High absolute birth weight; cut-off varies by context |
Serial SFH is a screen, not a diagnosis. A static/falling trajectory or discrepancy from dates prompts ultrasound biometry, liquor assessment and—when indicated—Doppler surveillance. The deck notes that routine ultrasound in an otherwise low-risk pregnancy had not shown clear effectiveness for detecting all growth problems [1]; high-risk pregnancies follow condition-specific scan schedules.
The two picture slides answer different questions [1]:
- Lie: relation of the fetal long axis to the uterine long axis—longitudinal, transverse or oblique.
- Presentation: fetal part at the pelvic inlet—cephalic, breech or shoulder. A transverse lie generally presents a shoulder.
Before 32–34 weeks, a non-cephalic lie in a patient not in labour often has little significance because there is room to turn. Most fetuses become longitudinal/cephalic by 35–36 weeks. For persistent breech after 36 weeks, assess suitability for ECV.
The ECV image shows a forward-roll sequence: the clinician elevates the breech out of the pelvis, guides the fetal poles through a forward or backward roll, and finishes with the vertex over the pelvis. It is an ultrasound/monitoring-supported hospital procedure performed by trained clinicians where urgent delivery is available—not a bedside manoeuvre to attempt casually.
4. The care system, birth planning and education
- Exclusive specialist hospital care, public or private.
- Primary-care or midwife-led care with referral when indicated.
- Shared care between hospital and primary care/Maternal and Child Health Centre [1].
Risk is dynamic. A patient may begin in a low-risk pathway and need escalation when hypertension, abnormal growth, multiple pregnancy or another complication appears.
The deck reviews the plan at about 36 weeks in an uncomplicated pregnancy [1]:
- allow spontaneous labour at term when mother and fetus remain well;
- consider earlier delivery when maternal or fetal compromise changes the balance;
- discuss induction around 41 weeks if pregnancy otherwise continues;
- aim for vaginal birth unless an obstetric or maternal indication favours caesarean delivery.
The slide includes antenatal classes/exercise, contraception, family involvement, social support, special needs and patient groups [1]. Practical counselling should also cover warning symptoms, fetal movements, medicines/substances, nutrition, folic acid before conception/early pregnancy, vaccination, feeding intentions, birth planning and postpartum contraception. Tailor advice rather than handing over an undifferentiated list.
If cervical screening is up to date, the lecture does not add a routine test solely because of pregnancy. If overdue, assess whether screening during pregnancy or planned postpartum screening is most appropriate under the local programme [1].
5. Pre-pregnancy counselling
Ask two directions of risk:
- How can the disease affect pregnancy and the fetus?
- How can pregnancy affect the disease?
Then convert that discussion into actions:
- define whether pregnancy is currently safe and when conception is best;
- optimise disease activity, organ function, nutrition, weight and glycaemic control;
- review every prescribed, over-the-counter and complementary medicine;
- choose effective contraception until optimisation is complete;
- assess recurrence/inheritance risk and arrange genetic counselling when relevant;
- plan specialist team, antenatal surveillance, delivery and postpartum care.
The lecture lists higher risks of miscarriage, FGR, preterm birth, pre-eclampsia, neonatal lupus and variable maternal flares [1]. Anti-Ro/SSA and anti-La/SSB antibodies are relevant to neonatal lupus and congenital heart block. Conception is safest when disease is quiescent and medications/renal status have been reviewed by rheumatology and maternal medicine.
| Medicine/context | Safe counselling principle |
|---|---|
| ACE inhibitor/ARB | Usually avoid in pregnancy; make a supervised antihypertensive plan before conception |
| Warfarin or a mechanical heart valve | Anticoagulation is highly individualised; do not simply “switch to LMWH” without an expert valve/obstetric plan |
| Methotrexate, mycophenolate, valproate and other teratogens | Review indication, safer alternatives, washout where needed and effective contraception with the relevant specialist |
| Hydroxychloroquine in SLE | Commonly continued because stopping may increase flare risk; confirm the individual plan |
| Diabetes therapy | Achieve safe preconception glycaemia and review drugs, retinal/renal status and folate plan |
The durable principle is do not stop an essential medicine abruptly and do not conceive until the disease and medicine plan are ready.
6. Linked exam extensions
| Trap | Better answer |
|---|---|
| “Low MCV means iron deficiency” | Check ferritin and the haemoglobinopathy pathway; both can coexist |
| “No HbH inclusions excludes α-thalassaemia” | α⁰ carrier status can be missed; genotype at-risk couples |
| “Pre-eclampsia requires proteinuria” | Organ or uteroplacental dysfunction can establish it without proteinuria |
| “Advanced age means screening first” | Offer screening and diagnostic options after informed counselling |
| “NIPT is diagnostic” | It analyses placental cfDNA and positive results require confirmatory CVS/amnio |
| “Late ultrasound can re-date the pregnancy” | Use a reliable early date; later size mainly assesses growth |
| “Lie and presentation are synonyms” | Lie is axis-to-axis; presentation is the fetal part at the pelvic inlet |
- 2020 Fourth Summative MCQ Q6–7: early OGTT in a patient with a diabetes risk factor [4].
- 2023 Fourth Summative MCQ Q13–14: hypertension/proteinuria classification and first-trimester aneuploidy screening [10].
- 2023 and 2025 Fourth Summative SAQs: antenatal screening and related pregnancy physiology [7][8].
- 2021 Fourth Summative MCQ Q9: supine hypotension [11].
Exact wording and mark allocation should be checked in the original papers.
High-yield summary
- Antenatal care combines prevention, screening and education.
- Read the thalassaemia chart as a couple-risk algorithm: woman → partner → characterise α/β status → fetal diagnosis when both can transmit severe disease.
- Date early; use later biometry to assess growth, not repeatedly change the due date.
- Pre-eclampsia is hypertension plus proteinuria or maternal/uteroplacental dysfunction.
- cfDNA/NIPT is highly accurate screening of placental DNA, not diagnosis.
- CVS samples placenta; amniocentesis samples amniotic fluid.
- Lie describes axes; presentation describes the part entering the pelvis.
- Preconception care optimises disease, medicines, inheritance risk and timing before contraception is stopped.
Active Recall - Antenatal Care and Pre-Pregnancy Counselling (Part I)
[1] Lecture slides: CFB (OGPAE01-1) Perinatal Medicine, Antenatal Care and Pre-pregnant Counselling (Part I).pdf (slides 1–43) [2] Lecture slides: CFB (PAE01) Paediatric history taking.pdf (p4) [3] Senior notes: Adrian Lui Obstetric Notes.pdf (p17, p24) [4] Past papers: 2020 Fourth Summative Assessment MCQ paper.pdf (p36, Q6–7) [5] Senior notes: Block A - Many members of the family have anaemia.pdf (p10, p36) [6] Senior notes: MBBS Final MB (Pediatrics) (Felix PY Lai).pdf (p589) [7] Past papers: 2025 Fourth Summative SAQ.pdf (p9, Q7) [8] Past papers: 2023 Fourth Summative SAQ.pdf (p3, Q2; p6, Q5) [10] Past papers: 2023 Fourth Summative MCQ.pdf (p6, Q13–14) [11] Past papers: 2021 Fourth Summative Assessment MCQ.pdf (p4, Q9) [13] Senior notes: Ryan Ho Fundamentals.pdf (p191) [14] Senior notes: Adrian Lui Pediatrics Notes.pdf (p20) [15] Lecture slides: Block C - O&G Theme Case 1.docx.pdf (p7) [16] Hong Kong College of Obstetricians and Gynaecologists: Guidelines of Antenatal Thalassaemia Screening [17] WHO recommendations on antenatal care for a positive pregnancy experience [18] NICE: Hypertension in pregnancy—diagnosis and management [19] ACOG: Current guidance on prenatal genetic screening and diagnostic testing
CFB PAE01 Paediatric History Taking
Paediatric history taking is the systematic process of gathering a child's clinical information—including presenting complaint, history of present illness, birth history, developmental milestones, immunisation status, feeding/nutrition, and family/social history—from the parent or caregiver to guide diagnosis and management.
CFB OGPAE01-2 Perinatal Medicine, Antenatal Care And Pre-pregnant Counselling (part II)
Continuation of perinatal medicine education covering advanced aspects of antenatal care, including screening strategies, management of high-risk pregnancies, and pre-pregnancy counselling to optimize maternal and fetal outcomes.